主要研究方向：1.细胞死亡的调控机制及其在代谢疾病中的作用；2.靶向诱导细胞死亡在肿瘤治疗中的创新疗法探索。
代表性研究成果发表在Cell Reports，Nat Commun，Hortic Res，Plant Cell，J Exp Bot和Front Plant Sci等杂志上；作为负责人主持国家自然科学基金1项，上海市自然科学基金1项。
Major areas of research and expertise include: 1. The regulatory mechanisms of cell death and their role in metabolic diseases. 2. The exploration of innovative cancer therapies through targeted induction of cell death. Dr. Ren has been published in journals including Cell Reports, Nature Communications, Horticulture Research, The Plant Cell, Journal of Experimental Botany, and Frontiers in Plant Science. Dr. Ren is the principal investigator of National Natural Science Foundation of China (NSFC) project and Shanghai Committee of Science and Technology.
【代表性论文（Publications）】
1. Ren W†, #, Jiang H†, Song Q†, Chen Y, Tang C, Wang F, Zhu J, Ren J, Zhao Y, He Y, Cai J, Zhang T, Wang Z, Zhu C, Xue W, Peng A, Feng X, Liu Y, Yu J, Liu ZG, Cai Z#. TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation. Cell Rep. 2025 Aug 21;44(9):116186. doi: 10.1016/j.celrep.2025.116186.
2. Ren W†, Medeiros N†, Warneford-Thomson R, Wulfridge P, Yan Q, Bian J, Sidoli S, Garcia BA, Skordalakes E, Joyce E, Bonasio R, Sarma K#. Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function. Nat Commun. 2020 May 6;11(1):2219. doi: 10.1038/s41467-020-15902-9.
3. Ren W, Wu F, Bai J, Li X, Yang X, Xue W, Liu H#, He Y#. BcpLH organizes a specific subset of microRNAs to form a leafy head in Chinese cabbage (Brassica rapa ssp. pekinensis). Hortic Res. 2020 Jan 1;7(1):1. doi: 10.1038/s41438-019-0222-7.
4. Ren W†, Wang H†, Bai J, Wu F, He Y#. Association of microRNAs with Types of Leaf Curvature in Brassica rapa. Front Plant Sci. 2018 Feb 6;9:73. doi:10.3389/fpls.2018.00073.
5. Chen Y†, Ren W†, Wang Q, He Y, Ma D, Cai Z. The regulation of necroptosis by ubiquitylation. Apoptosis. 2022 Oct;27(9-10):668-684. doi: 10.1007/s10495-022-01755-8.
6. Yang X†, Dong W†, Ren W†, Zhao Q, Wu F, He Y#. Cytoplasmic HYL1 modulates miRNA-mediated translational repression. Plant Cell. 2021 Jul 19;33(6):1980-1996. doi: 10.1093/plcell/koab090.
7. Dong W†, Ren W†, Wang X, Mao Y, He Y#. MicroRNA319a regulates plant resistance to Sclerotinia stem rot. J Exp Bot. 2021 May 4;72(10):3540-3553. doi: 10.1093/jxb/erab070.
