主要从事基于DNA编解码的精准医学诊断新技术开发及其临床应用研究。目前已在Chem (2篇), Nat Commun, Sci Adv, J Am Chem Soc, Angew Chem Int Ed (2篇)等期刊发表SCI论文40余篇，25篇IF>10，累计被引1200余次；申请发明专利20项，授权8项，2项专利已转化；主持国家自然科学基金项目、科技部重点研发项目子任务、上海市面上项目等纵向项目7项；荣获全国颠覆性技术创新大赛优胜奖、上海市春昇杯医学创新人才大赛优胜奖、上海市卫生健康行业青年创新大赛金奖等，入选上海市启明星计划杨帆专项人才、国家技术转移人才中级技术纪经人（医疗产业）。
1. Dongsheng Mao#, Hongquan Gou#, Wen Chen, Rui Zhu, Fanping Zhang, Wentao Zhang, Yuanyuan Zhang, Xiaozhi Huang, Min Li, Wenxing Li*, Bing Shen*, Xiaoli Zhu*, Enzymatic DNA Orthogonal Chemistry for Multi-Cancer Diagnosis. Chem, 2025, 11, 102656.（中科院1区TOP，IF=19.6）
2. Dongsheng Mao#, Wenxing Li#, Xueliang Liu, Jingqi Chen, Dali Wei, Lei Luo, Qianqin Yuan, Yu Yang*, Xiaoli Zhu*, Weihong Tan, Rolling circle amplification-based DNA-enzyme nanostructure for immobilization and functionalization of enzymes. Chem, 2025, 11, 102335.（中科院1区TOP，IF=19.6）
3. Dongsheng Mao#, Fanping Zhang#, Hanhua Li, Yazhou Wu, Zhenzhen Zhang, Hongquan Gou, Rui Zhu, Yingchuan Li*, Wenhao Weng*, Xiaoli Zhu*. Spectral Fingerprint Diagnosis: Spatially Independent Analysis of Biomarker Patterns in Homogeneous System. Accepted. （中科院1区TOP，IF=12.5）
4. Dongsheng Mao#, Xiaochen Tang#, Runchi Zhang, Song Hu, Hongquan Gou, Yichun Mao, Wenxing Li*, Qiuhui Pan*, Bing Shen*, Xiaoli Zhu*, Multichrome encoding-based multiplexed, spatially resolved imaging reveals single-cell RNA epigenetic modifications heterogeneity. Nature Communications, 2025, 16, 958.（中科院1区TOP，IF=15.7）
5. Dongsheng Mao#, Xiaochen Tang#, Runchi Zhang#, Tianshu Chen, Chenbin Liu, Hongquan Gou, Pei Sun, Yichun Mao, Jie Deng, Wenxing Li*, Fenyong Sun*, Xiaoli Zhu*. DNA-programmed four-bit quaternary fluorescence encoding (FLUCO) enables 51-colored bioimaging analysis. Journal of the American Chemical Society, 2024, 146, 24, 16428-16439.（中科院1区TOP，IF=15.6）
6. Dongsheng Mao#, Mengmeng Zheng#, Wenxing Li#, Yi Xu, Chengguang Wang, Qiuling Qian, Shuainan Li, Guifang Chen*, Xiaoli Zhu*, Xianqiang Mi*, Cubic DNA nanocage-based three-dimensional molecular beacon for accurate detection of exosomal miRNAs in confined spaces. Biosensors and Bioelectronics, 2022, 204, 114077.（中科院1区TOP，IF=12.6）
7. Xiaohao Liu#, Dongsheng Mao#, Yuchen Song, Albertina N Isak, Cuicui Lu, Guoli Deng, Fenyong Sun*, Yu Yang*, Xiaoli Zhu,* Weihong Tan*, Computer-aided design of reversible hybridization chain reaction (CAD-HCR) enables multiplexed single-cell spatial proteomics imaging. Science Advances, 2022, 8, 2, eabk0133.（中科院1区TOP，IF=13.6）
8. Yang Wang#, Huaxing Li#, Xiangqian Cao#, Weiguang Zhao, Hongquan Gou, Chenkai Yang, Haoyuan Wang, Jie Deng, Wen Chen, Haipeng Qi, Dongsheng Mao*, Xiaoli Zhu*, Bing Shen*. In situ multiplexed imaging of miRNA heterogeneity in single urinary exosome enables non-invasive bladder cancer diagnosis. Chemical Engineering Journal, 2025, 523, 168311.（中科院1区TOP，IF=13.2）
9. Xiaoxia Mao, Mengqin Shi, Chen Chen, Jingkang Guo, Shaowei Liu, Hongquan Gou, Xiaoli Zhu*, Wenxing Li*, Dongsheng Mao*. Metal-organic framework integrated hydrogel bioreactor for smart detection of metal ions. Biosensors and Bioelectronics, 2024, 247, 115919.（中科院1区TOP，IF=10.5）
10. Tianshu Chen#, Siwei Mao#, Ji Ma#, Xiaochen Tang, Rui Zhu, Dongsheng Mao*, Xiaoli Zhu*, Qiuhui Pan*, Proximity-Enhanced Functional Imaging Analysis of Engineered Tumors. Angewandte Chemie International Edition, 2024, 63, 14, e202319117.（中科院1区TOP，IF=16.9）
