以项目负责人获得国家自然科学基金6项以及10余项省部级、局级等课题。以第一/通讯作者在PNAS，Moleular Cancer，Cancer research等国际著名杂志发表60余篇SCI论著。主编著作3部，授权发明专利3项。入选上海市东方英才计划拔尖项目，上海市卫健委优秀学科带头人计划（新百人），上海市临床康复优秀学科带头人，上海市科委浦江人才计划，87978797威尼斯老品牌“十佳医务青年”等 。以主要完成人员获得科技进步奖4项，包括上海市康复医学科技奖二等奖，华夏医学科技奖二等奖，中华医学科技奖一等奖，上海医学科技奖一等奖，教育部高等学校科学研究优秀成果奖自然科学一等奖。
【近五年负责课题】
2025.1-2028.12国家自然科学基金面上项目(82472360）
2021.1-2024.12 国家自然科学基金面上项目（82072362）
2019.1-2022.12 国家自然科学基金面上项目（81873975）
2020-2023 上海市公共卫生重点学科建设（GWV-10.1-XK04）
2022.7-2024.9 上海市促进市级医院临床技能与临床创新三年行动计划-病原体核酸现场快速检测系统（SHDC2022CRD040）
2023-2026 市级医院诊疗技术推广及优化管理促进临床专科能力提升上海市级医院检验专科联盟（SHDC22023303）
2023-2026 教育部产学合作育人项目（231107010081311）
2023-2026 上海市创新医疗器械示范项目子课题（23SH06200）
2021~2023 幽门螺杆菌gyrA型基因突变检测试剂盒（PCR-荧光探针法）的临床研究（PKX2021-S08）
【代表性文章】
Chen C, Gao Y, Lu R, Wu Y, Yao Y, Sun R, Wu J, Ji P, Quan W, Wu D, Sun Z, Li D. TERC Stimulates Fatty Acid Metabolism to Promote Bladder Cancer Progression. Cancer Res. 2025 Oct 1;85(19):3689-3705.
Liu G, Wu J, Yang B, Kong J, Li Y, Chen C, Hu J, Sun Z, Hou Y, Sun R, Li D. Ultrasensitive eccDNA Detection for Tumor Diagnostics by Using CRISPR/Cas12a-Coupled Nested PCR. Anal Chem. 2025 Sep 2;97(34):18527-18536.
Wang H, Peng H, Zhang Z, Abulimiti Y, Hu J, Zhou Y, Ji P, Li D. FTO-mediated m6A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer. Clin Transl Med. 2025 Jul;15(7):e70392.
Chen C, Wu Y, Wu J, Sun R, Li Y, Yao Y, Li D. Identification of a panel of lncRNAs derived from urinary extracellular vesicles as non-invasive diagnostic biomarkers for bladder cancer. Clin Chim Acta. 2025 Jul 15;575:120376.
Ping Y, Huang J, Zhu J, Sun Z, Shang A, Chen C, Liu W, Li D. Comprehensive analyses of molecular features, prognostic values, and regulatory functionalities of m6A-modified long non-coding RNAs in lung adenocarcinoma. Clin Epigenetics. 2023 Apr 7;15(1):60.
Chang W, Zhu J, Yang D, Shang A, Sun Z, Quan W, Li D. Plasma versican and plasma exosomal versican as potential diagnostic markers for non-small cell lung cancer. Respir Res. 2023 May 31;24(1):140.
Gu C, Shang A, Liu G, Zhu J, Zhang W, Jin L, Sun Z, Li D. Identification of CD147-positive extracellular vesicles as novel non-invasive biomarkers for the diagnosis and prognosis of colorectal cancer. Clin Chim Acta. 2023 Aug 1;548:117510.
Shang A, Gu C, Wang W, Wang X, Sun J, Zeng B, Chen C, Chang W, Ping Y, Ji P, Wu J, Quan W, Yao Y, Zhou Y, Sun Z, Li D. Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-β1 axis. Mol Cancer. 2020 Jul 27;19(1):117.
Sun J, Wang X, Liu W, Ji P, Shang A, Wu J, Zhou H, Quan W, Yao Y, Yang Y, Gu C, Sun Z, Goel A, Weng W, Li D. Novel evidence for retinoic acid-induced G (Rig-G) as a tumor suppressor by activating p53 signaling pathway in lung cancer. FASEB J. 2020 Sep;34(9):11900-11912.
Shang A, Gu C, Zhou C, Yang Y, Chen C, Zeng B, Wu J, Lu W, Wang W, Sun Z, Li D. Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration of colorectal cancer by inducing IL-8 expression. Cell Commun Signal. 2020 Mar 30;18(1):52.
Shang A, Wang W, Gu C, Chen C, Zeng B, Yang Y, Ji P, Sun J, Wu J, Lu W, Sun Z, Li D. Long non-coding RNA HOTTIP enhances IL-6 expression to potentiate immune escape of ovarian cancer cells by upregulating the expression of PD-L1 in neutrophils. J Exp Clin Cancer Res. 2019 Sep 18;38(1):411.
Ji P, Zhou Y, Yang Y, Wu J, Zhou H, Quan W, Sun J, Yao Y, Shang A, Gu C, Zeng B, Firrman J, Xiao W, Bals R, Sun Z, Li D. Myeloid cell-derived LL-37 promotes lung cancer growth by activating Wnt/β-catenin signaling. Theranostics. 2019 Apr 12;9(8):2209-2223.
